New Orleans Saints (0-0) vs. Detroit Lions (0-0) September 13, 2026 1:00 pm EDT The Line: Detroit Lions -6.5; Over/Under: 49.5 (Get latest betting odds)
In this article, we will formulate a Saints vs Lions Prediction for this NFL Week 1 game on Sunday, September 13 th . Let’s take a look at the prediction for this NFL matchup.
The Lions finished the preseason with a 2-1 record and were placed 2nd in the NFC North. They had a 1-0 home record and a 1-1 road record. They are coming off a 25-16 road victory over the Colts, where they outgained their opponents 356 to 229 total yards and had 25 first downs. The Detroit Lions had 170 passing yards, 186 rushing yards, while winning the turnover battle by 1-4. They went 13/19 on third down conversions and 4/4 in the red zone.
Offensively in the preseason, the Lions averaged 18.7 points per game, while allowing 15 points per game defensively. Detroit averaged 303 total yards per game (141.7 passing and 161.3 rushing), while allowing 242.7 total yards per game (187.3 passing and 55.3 rushing).
The Saints finished the preseason with a 1-2 record and were placed 4th in the NFC South. They had a 0-1 home record and a 1-1 road record. They are coming off a 27-24 road victory over the Cowboys, where they outgained their opponents 326 to 328 total yards and had 23 first downs. The New Orleans Saints had 157 passing yards, 169 rushing yards, while the turnover battle was tied at 0-0. They went 3/9 on third down conversions and 3/4 in the red zone.
Offensively in the preseason, the Saints averaged 15.7 points per game, while allowing 27.3 points per game defensively. New Orleans averaged 298.7 total yards per game (188.7 passing and 110 rushing), while allowing 336 total yards per game (216 passing and 120 rushing).
In this Saints vs Lions Prediction, the Lions are coming as -6.5 home favorites. the Lions looked much better in the preseason, winning two of their three games and playing very good defense, holding opponents into just 15 ppg, 12.3 points fewer than the struggling Saints. On top of that, New Orleans also struggled offensively and had a -11.6 point differential in the preseason and are 2-4 in their last 6 meetings against the Lions. I like the hosts to take care of business in their season opener at home and cover the -6.5 number.