Buffalo Bills (0-0) vs. Houston Texans (0-0) September 13, 2026 1:00 pm EDT The Line: Houston Texans +1.5; Over/Under: 44.5 (Get latest betting odds)
In this article we will formulate a Texans vs Bills prediction for this NFL game on Sunday, September 13th at Reliant Stadium in Houston, Texas. Let’s take a look at the prediction for this week 1 matchup.
The Houston Texans went 12-5 last season and they finished second in the AFC South standings, one game behind the Jaguars in first. Houston started the season with a 14-9 loss to the Rams and followed that up with a 20-19 loss to the Buccaneers. The Texans were just 3-5 through eight games, but they won each of their last nine games to finish the regular season strong. Houston played great defense down the stretch, as they allowed 21 or fewer in seven of their last eight games. The Texans did defeat the Steelers 30-6 in the playoffs, but lost to the Patriots by a score of 28-16. Houston scored 23.8 points per game in 2025, while they allowed 17.4 points against per game on defense.
In the preseason, Houston went 0-3, which was dead last in the AFC South. The Texans lost to the Chargers by a score of 27-7, lost to the Raiders by a score of 22-20, and lost to the Panthers by a score of 16-13 in their three games. Houston will have CJ Stroud at quarterback with David Montgomery at running back and Nico Collins as the #1 receiver.
The Buffalo Bills were 12-5 last year and they finished second in the AFC East, which was two games behind the Patriots in first. Buffalo started the season with a 41-40 win against the Ravens and a 30-10 win over the Jets. The Bills were 7-4 through 11 games, but they went 5-1 in their last six. Buffalo had a great offense last year and they scored 35+ points in four of their last eight games. The Bills defeated the Jaguars by a score of 27-24 in the playoffs, but lost to the Broncos by a score of 33-30 in overtime. Buffalo scored 28.3 points per game in 2025, while they allowed 21.5 points against per game on defense.
In the preseason, Buffalo went 3-0, which was first in the AFC East. The Bills defeated the Panthers by a score of 29-14, defeated the Browns by a score of 31-7, and defeated the Steelers by a score of 28-27 in their three games. Buffalo will have Josh Allen at quarterback with James Cook at running back and DJ Moore at receiver.
Both of these teams went 12-5 last year and made the playoffs, so this is a great matchup for week one. Buffalo has one of the best quarterbacks in the NFL, but Houston is an elite defensive team. The Texans are led by their defense, as Stroud and the offense have not been good enough in recent years. I know Buffalo will struggle against this defensive scheme, especially in a week one game, but I won’t back CJ Stroud here. Take the Bills to win.