Houston Astros (51-54) vs. Chicago White Sox (54-48) July 25, 2026 7:10 pm EDT The Line: Chicago White Sox -126 / Houston Astros +105; Over/Under: 8.5 (Get latest betting odds)
The Houston Astros and the Chicago White Sox meet Saturday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Chicago White Sox prediction.
The Houston Astros will send out Hunter Brown for the start here and Brown is 1-1 with a 4.05 ERA and 43 strikeouts this season. Sean Burke will start for Chicago and is 7-4 with a 3.20 ERA and 120 strikeouts this season.
The Houston Astros come into this game looking to add on to their 9-5 win over the White Sox from Friday to sit at 51-54 this season. After this series, the Astros will head on the road for a series against the Los Angeles Angels.
Yordan Alvarez has 123 hits with 20 doubles, 34 home runs and 77 RBIs while Christian Walker has 88 hits with 20 doubles, 20 home runs and 61 RBIs on the year. Jose Altuve’s chipped in 74 hits with 14 doubles, 12 home runs and 30 RBIs and Isaac Paredes has 93 hits with 18 doubles, 14 home runs and 54 RBIs. Cam Smith also has 71 hits with 13 doubles, 13 home runs and 36 RBIs.
The Chicago White Sox come into this game looking to bounce back from their loss to Houston on Friday to fall to 54-48 this season. After this series, the White Sox will take on the Yankees in a series at home.
Munetaka Murakami has 54 hits with 20 home runs and 42 RBIs while Miguel Vargas has 90 hits with 24 doubles, a triple, 21 home runs and 61 RBIs and Colson Montgomery has 79 hits with 17 doubles, 24 home runs and 58 RBIs. Luisangel Acuna has 38 hits and Tristan Peters has 78 hits with 21 doubles and 37 RBIs so far this season. Chase Meidroth also has 102 hits with 18 doubles, 7 home runs and 36 RBIs this year.
I’m on the White Sox in this one. Hunter Brown just hasn’t looked like the Hunter Brown we are used to seeing year after year for Houston, and I think the White Sox can exploit that here. Sean Burke has been outstanding in a lot of his recent outings and I think if it wasn’t for one bad inning on Friday, we’d be talking about a different result. I’ll back Chicago here.