St. Louis Cardinals (72-73) vs. San Francisco Giants (60-85) September 8, 2026 9:45 pm EDT The Line: San Francisco Giants -111 / St. Louis Cardinals -108; Over/Under: 7.5 (Get latest betting odds)
The St. Louis Cardinals and the San Francisco Giants meet Tuesday in MLB action from Coors Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. San Francisco Giants prediction.
The St. Louis Cardinals will send out Quinn Mathews for the start here and Mathews is 1-2 with a 4.38 ERA and 24 strikeouts this season. Landen Roupp will start for San Francisco and is 8-13 with a 4.17 ERA and 137 strikeouts this season.
The St. Louis Cardinals come into this game looking to bounce back from a 5-4 loss at the hands of the Giants on Monday to sit at 72-73 this season. After this series, the Cardinals will head home for a series against the Chicago White Sox.
Entering Monday, Jordan Walker has 156 hits, 32 doubles, 28 home runs and 100 RBIs while Alec Burleson has 155 hits with 34 doubles, 21 home runs and 103 RBIs. JJ Wetherholt has 122 hits with 17 home runs and 48 RBIs while Ivan Herrera has 136 hits with 25 doubles, 16 home runs and 64 RBIs. Masyn Winn’s added 103 hits with 19 doubles and 51 RBIs and Nathan Church has 91 hits with 10 home runs and 48 RBIs this season.
The San Francisco Giants come into this game looking to add on to their win over the Cardinals from Monday’s matchup to sit at 60-85 this season. After this series, the Giants will take on the San Diego Padres in a series at home.
Going into Monday, Willy Adames has 107 hits with 25 doubles, 21 home runs and 51 RBIs along with 139 strikeouts. Matt Chapman has 72 hits with 18 doubles, a triple, 7 home runs and 42 RBIs and Jung Hoo Lee has 139 hits with 28 doubles, 4 triples, 9 home runs and 53 RBIs. Rafael Devers also has 140 hits with 34 doubles, 35 home runs and 91 RBIs but also has 158 strikeouts this season.
I’m on the Giants here. Roupp hasn’t had the biggest amount of success for San Francisco this season but a lot of that has to do with an offense that a lot of times refused to back him up. St. Louis is the better team that’s attempting to play for something, but I don’t think the Giants back down here. I don’t love Quinn Mathews as a starting option, and I think the Giants do enough to pick up another win and deal another blow to St. Louis’ playoff hopes. Give me the Giants.